2000 Jan;22(1):39-43. Alldredge BK, Corelli RL, Ernst ME, Guglielmo BJ, eds. Although anaphylactic reactions known to occur following INFeD administration are usually evident within a few minutes, or sooner, it is recommended that a period of an hour or longer elapse before the remainder of the initial therapeutic dose is given. 0.5 mg/kg (not to exceed 100 mg/dose) diluted to a concentration of 1 to 2 mg/mL in 0.9% sodium chloride IV over 5 to 60 minutes Administer every 4 weeks for 12 weeks Do not dilute to concentrations below 1 mg/mL Comments: Treatment may be repeated if necessary. The plasma ferritin level as a reliable index of body iron stores following intravenous iron dextran. Allow at least 30 minutes between administration of Feraheme and administration of other medications that could potentially cause serious hypersensitivity reactions and/or hypotension, such as chemotherapeutic agents or monoclonal antibodies. Consult your doctor before breast-feeding. A: Generally acceptable. This drug is available at a middle level co-pay. Either increases effects of the other by pharmacodynamic synergism. Iron sucrose: 20 mg/mL. Serious - Use Alternative (1)iron sucrose decreases levels of gemifloxacin by inhibition of GI absorption. Applies only to oral form of both agents. A target haemoglobin value is also input so iron deficit can be determined according to a specified individual target. It varies from increases in dietary intake of iron (usually for prophylaxis purposes) to oral, intramuscular or intravenous therapy. Individual doses of 2 mL or less may be given on a daily basis until the calculated total amount required has been reached. Suggested regime: Prescribing instructions Prescribing a single/first dose: Minor/Significance Unknown. iron sucrose decreases levels of oxytetracycline by inhibition of GI absorption. Untreated IDA in pregnancy is associated with adverse maternal outcomes such as post-partum anemia. however iron sucrose requires multiple small intermittent doses over days to weeks. Applies only to oral form of both agents. Applies only to oral form of both agents. Use alternatives if available. In most cases, adult patients require a cumulative dose of elemental iron of at least 1 g. Most commonly, iron replenishment therapy is done intravenously: As total dose (iron-dextran or iron carboxymaltose); Iron deficiency is common during childhood growth, prolonged periods of sickness, in convalescence or during pregnancy. Applies only to oral form of both agents. ONE DOSE. Monitor Closely (1)iron sucrose decreases levels of liothyronine by inhibition of GI absorption. provider for the most current information. Below the form there are further instructions on how to use the calculator. lansoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. MISSED DOSE: It is important to get each dose of this medication as scheduled. 1) Ganzoni AM. Ferrlecit has been administered at sequential dialysis sessions by infusion or by slow intravenous injection during the dialysis session itself. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Applies only to oral form of both agents. The original formula employs the weight in kg but users can input it in lbs and it gets transformed. 1970; 100(7):301-3. In less advanced cases of iron deficiency, increases in dietary intake of iron may be sufficient. Recommended dosing and infusion rates for PI. Use Caution/Monitor.Minor (2)calcium carbonate decreases levels of iron sucrose by inhibition of GI absorption. The factor 2.4 is derived from the following assumptions: a) Blood volume 70 ml/kg of body weight ~7% of body weight b) Iron content of hemoglobin 0.34% Factor 2.4 = 0.0034 x 0.07 x 10000 (conversion for g/dL) Ganzoni AM. Copyright 2014 - 2023 The Calculator .CO |All Rights Reserved|Terms and Conditions of Use, Intravenous iron-dextran: therapeutic and experimental possibilities, Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations, Treatment of iron deficiency anemia associated with gastrointestinal tract diseases, Diagnosis and management of iron deficiency anaemia: a clinical update. Applies only to oral form of both agents. Applies only to oral form of both agents. Serious - Use Alternative (1)iron sucrose will decrease the level or effect of baloxavir marboxil by cation binding in GI tract. 4) Gozzard D. (2011) When is high-dose intravenous iron repletion needed? If hypersensitivity reactions or signs of intolerance occur during administration, stop Venofer immediately. SIDE EFFECTS: Muscle cramps, nausea, vomiting, strange taste in the mouth, diarrhea, constipation, headache, cough, back pain, joint pain, dizziness, or swelling of the arms/legs may occur. Monitor Closely (1)sodium sulfate/?magnesium sulfate/potassium chloride decreases levels of iron sucrose by inhibition of GI absorption. Either decreases levels of the other by inhibition of GI absorption. FERAHEME was non-inferior to Venofer (iron sucrose) in mean Hgb rise from baseline 2,5. Monitor for signs and symptoms of hypotension following each Feraheme infusion. Applies only to oral form of both agents. Applies only to oral form of both agents. Administer Venofer in 3 divided doses, given by slow intravenous infusion, within a 28 day period: 2 infusions each of 300 mg over 1.5 hours 14 days apart followed by one 400 mg infusion over 2.5 hours 14 days later. You may need extra iron because of blood loss during kidney dialysis. Studies in monkeys showed concurrent use with calcium, aluminum, or iron caused significantly decreased plasma levels. Use Caution/Monitor. Applies only to oral form of both agents. Use Caution/Monitor. Avoid or Use Alternate Drug. Patients diagnosed with iron deficiency are prescribed iron supplementation, either to replete body stores or to correct anemia. esomeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Please confirm that you would like to log out of Medscape. Monitor Closely (1)sodium sulfate/potassium sulfate/magnesium sulfate decreases levels of iron sucrose by inhibition of GI absorption. Each mL contains 20 mg of elemental iron. Oral iron therapy is the first method while IV therapy comes in place when there are contraindications or the body doesnt respond to the oral one. Monitor Closely (1)rabeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. We'll do this entirely for free, as long as the calculator has applications for women's health. Applies only to oral form of both agents. aluminum hydroxide will decrease the level or effect of iron sucrose by increasing gastric pH. Minor/Significance Unknown. Use Caution/Monitor. Applies only to oral form of both agents. In this study and another study evaluating a single intravenous dose of iron sucrose containing 500-700 mg of iron in 26 anemic patients on erythropoietin therapy (23 female, 3 male; age range 16-60), approximately 5% of the iron was . For males: LBW = 50 kg + 2.3 kg for each inch of patients height over 5 feet For females: LBW = 45.5 kg + 2.3 kg for each inch of patients height over 5 feet. Do not administer Venofer to patients with iron overload. Monitor Closely (1)iron sucrose decreases levels of ibandronate by inhibition of GI absorption. Venofer (iron sucrose injection, USP) For Intravenous Use Only INDICATION AND USAGE Venofer (iron sucrose injection, USP) is indicated for the treatment of iron deficiency anemia (IDA) in patients with chronic kidney disease (CKD). Follow your doctor's directions carefully.Tell your doctor right away if you have any serious side effects, including: abdominal pain, chest pain, irregular heartbeat (arrhythmias), pressure in the chest, severe headache and blurred vision (hypertension), problems with your dialysis access site (graft).A very serious allergic reaction to this drug is unlikely, but get medical help right away if it occurs. In: Koda-Kimble & Young's Applied Therapeutics: The Clinical Use of Drugs. Maximum single dose of iron sucrose to be given at a time in Non-dialysis CKD patients is 500 mg but with limited experience. Applies only to oral form of both agents. Injection: 50 mg/2.5 mL, 100 mg/5 mL, or 200 mg/10 mL (20 mg/mL) in single-dose vials. Med J Aust. The dosage is expressed in terms of mg of elemental iron, with each mL of Feraheme containing 30 mg of elemental iron. Applies only to oral form of both agents. Maximum infusion rate: 100 mg / hour (Slow infusion rate of iron sucrose is recommended to minimize adverse reactions, especially hypotension) Frequency of infusion: Dose may be repeated up to 3 times weekly to provide total iron dose. The Ganzoni equation used by the iron deficiency calculator is the following: Total iron deficit (mg) = Weight in kg x (Target Hb - Actual Hb in g/dL) x 2.4 + Iron stores. omeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. The two formulas used are presented below: Iron deficit in mg = Weight in kg x (14 - Hb in g/dL) x 2.145 Volume of product required in mL = Iron deficit in mg / C in mg/mL Where C is the concentration of the iron product: 50 mg/mL for Iron dextran; 20 mg/mL for Iron sucrose; 5 mg/mL for Ferric gluconate. Use Caution/Monitor. Applies only to oral form of both agents. Applies only to oral form of both agents. Minor (1)iron sucrose decreases levels of manganese by inhibition of GI absorption. The recommended Feraheme dose may be readministered to patients with persistent or recurrent iron deficiency anemia. Discuss the risks and benefits with your doctor.This medication passes into breast milk. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every two weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at a concentration of 1 to 2 mg/mL and administered over 5 to 60 minutes. Calculosaurus | Medical calculators for obstetrics and gynaecology Use the menu to browse through our clinical calculators. Accessed: 4/12/2011. Avoid or Use Alternate Drug. You can further save the PDF or print it. Use Caution/Monitor. Intravenous therapy is preferred for urgent intervention and when oral iron cannot be absorbed or the patient suffers from chronic renal impairment. Volume of iron product required = 25 mL. Minor/Significance Unknown. Venofer must only be administered intravenously either by slow injection or by infusion. Applies only to oral form of both agents. All Rights Reserved. iron sucrose decreases levels of thyroid desiccated by inhibition of GI absorption. In case a pediatric patient with a weight below 35 kg is assessed, iron stores are calculated as 15 mg iron for each kg. iron sucrose will decrease the level or effect of baloxavir marboxil by cation binding in GI tract. 4. If either is present, do not use the liquid. Minor/Significance Unknown. Applies only to oral form of both agents. Venofer treatment may be repeated if necessary. Human studies not conducted. Minor/Significance Unknown.iron sucrose increases levels of calcium gluconate by enhancing GI absorption. ]Venofer treatment may be repeated if iron deficiency reoccurs. INFED- iron dextran injection [Package insert], Hemoglobin iron deficit (mg) = weight (kg) x (14 - Hgb) x (2.145) Note: Hbg (current hemoglobin level) units: (g/dL) Alternatively: Volume of product required (mL) = [weight (kg) x (14 - Hgb) x (2.145)] / C Where C= concentration of elemental iron (mg/ml) in the product being used: Iron dextran: 50 mg/mL. Applies only to oral form of both agents. 2. If we don't have the calculator you need then tell us the details and we'll make it for you. For patients receiving hemodialysis, administer Feraheme once the blood pressure is stable and the patient has completed at least one hour of hemodialysis. informational and educational purposes only. Otherwise, call a poison control center right away. Administer iron products at least 2 hr before and no less than 6 hr after each dose to avoid chelation with magnesium. Parenteral iron dextran therapy: a review. iron sucrose decreases levels of fleroxacin by inhibition of GI absorption. Symptoms associated with Venofer total dosage or infusing too rapidly included hypotension, dyspnea, headache, vomiting, nausea, dizziness, joint aches, paresthesia, abdominal and muscle pain, edema and cardiovascular collapse. Each mL contains 20 mg of elemental . It is usually given slowly over 2 to 5 minutes or as directed by your doctor. Venofer can be given as a maximum of 200mg not more than 3 times per week; doses must be 24 hours apart. Iron sucrose can also be mixed in a saline solution and given through an IV over a longer time. J Lab Clin Med. Use Caution/Monitor. Applies only to oral form of both agents. Drug Des Devel Ther; 5: 5160. Minor/Significance Unknown. Avoid or Use Alternate Drug. Use Caution/Monitor. Patients measured hemoglobin can be input in g/dL or mmol/L. This drug is available at a higher level co-pay. PRECAUTIONS: Before using iron sucrose, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. 2 DOSAGE AND ADMINISTRATION 2.1 Recommended Dosage Recommended dosage for patients weighing 50kg (110lb) or more: Give Injectaferin two doses separated by at least 7 days. Philadelphia, PA: Lippincott Williams & Wilkins;2013;303-307. 0.5 mg/kg/min (0.005 mL/kg/min) Maximum infusion rate (if tolerated) Increase to 8 mg/kg/min (0.08 mL/kg/min) Monitor the patient's vital signs throughout the infusion. Administer ciprofloxacin at least 2 hours before or 6 hours after using these products. Other indications for IV are pregnancy iron deficiency, chronic renal impairment or need for rapid repletion. NOTES: Lab and/or medical tests (such as complete blood count, ferritin, transferrin, total iron binding capacity-TIBC) should be done while you are using this medication. Results: Twelve children (6 females) aged 1.2-14 years (median age 8.9 years) received at least one dose of . Am J HealthSyst Pharm 2006;63:731735. Serious - Use Alternative (1)iron sucrose decreases levels of ofloxacin by inhibition of GI absorption. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. The dosage of iron sucrose is expressed in mg of elemental iron. Modify Therapy/Monitor Closely. commonly, these are generic drugs. Corrected Calcium. Ferric gluconate: 12.5 mg/mL. Serious - Use Alternative (1)iron sucrose decreases levels of mycophenolate by inhibition of GI absorption.